Radiolabeled In Vivo PK/ADME Study Services

In the realm of drug development and research, understanding the pharmacokinetics (PK) and absorption, distribution, metabolism, and excretion (ADME) properties of a compound is crucial. Radiolabeled in vivo PK/ADME studies provide invaluable insights into these dynamics. By labeling drugs with radioactive isotopes like carbon-14 or tritium, researchers can track their movement and concentration in various tissues over time. These studies focus on quantitatively analyzing drug concentration in plasma, tissues, and excreta, assessing absorption rates, mapping distribution in organs, identifying metabolic pathways, and understanding excretion routes. They are particularly important in early drug development stages for dose selection, formulation optimization, and ensuring safety. At Alfa Chemistry, we provide comprehensive preclinical radiolabeled in vivo PK/ADME study services. Our approach combines cutting-edge technology with scientific expertise to deliver high-quality, actionable data.

Our Radiolabeled In Vivo PK/ADME Study Services

• Customized Radiolabel Synthesis: We offer custom solution in synthesizing radiolabeled compounds using isotopes such as carbon-14 and tritium for in vivo PK/ADME study. We ensure high radiochemical purity and stability, essential for accurate in vivo studies.
• Mass Balance and Excretion Analysis: Our team conducts total radioactivity analysis to evaluate mass balance, excretion pathways, and excretion rates across urine, feces, and bile.
• Metabolite Analysis and Identification (MetID): Using advanced techniques, we perform detailed metabolite profiling and structural elucidation to uncover metabolic pathways and identify potential drug-drug interaction risks.
• Pharmacokinetics and Parameter Analysis: We provide precise PK parameter calculations, including bioavailability, half-life, and clearance rates, for preclinical studies.
• Tissue Distribution Studies: Our studies enable detailed spatial and temporal mapping of drug distribution across tissues, helping researchers understand the organ-specific effects of compounds. This includes quantitative whole-body autoradiography (QWBA), tissue dissection and microautoradiography.
• Plasma Protein Binding Studies: We measure the extent of plasma protein binding, a key determinant of a drug's bioavailability and therapeutic efficacy.
• Blood/Plasma Concentration-Time Profiles: We construct comprehensive concentration-time curves for total radioactivity in blood and plasma to elucidate systemic drug exposure.

Our Capacities

Alfa Chemistry owns multiple capacities to meet the demands of radiolabeled in vivo PK/ADME studies:

• Versatile Compound Labeling: We can synthesize 14C- and 3H-labeled compounds, accommodating a broad spectrum of chemical entities, including small molecules, peptides, ADCs, and oligonucleotides.
• Flexible Dosing Regimens: For in vivo PK/ADME studies, we support various dosing protocols, including single-dose, repeated-dose, and combination therapies, across multiple administration routes such as oral, intravenous, intraperitoneal, subcutaneous, intrathecal, intramuscular, and intranasal delivery.
• Diverse Animal Models: Our services encompass a range of animal species and models, tailored to the specific needs of your research. This includes small rodents and large animal models.
• Advanced Analytical Techniques: We ensure unparalleled sensitivity and accuracy in PK/ADME studies by utilizing liquid scintillation counting and accelerator mass spectrometry (AMS).
• Cutting-Edge Imaging Technology: Equipped with advanced imaging systems, we can provide in vivo visualization of drug distribution and localization.

Why Partner with Us?

Radiolabeled in vivo PK/ADME studies are indispensable for modern drug development, offering unparalleled insights into drug behavior. Our comprehensive radiolabeled in vivo PK/ADME studies services, combined with cutting-edge technology and an expert team, position us as a trusted partner in your research journey. Contact us today to learn more about how we can support your research and development goals.

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Radiolabeled In Vivo PK/ADME Study Services

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