Tissue Distribution Studies Service - Isotope Science / Alfa Chemistry

Our Technologies in Tissue Distribution Studies

Alfa Chemistry offers tissue distribution services tailored to meet the diverse needs of pharmaceutical and biotech companies. By leveraging state-of-the-art radiochemical technologies, we deliver detailed data that helps elucidate the pharmacokinetics and tissue-specific accumulation of drug candidates. Our technologies include:

Quantitative Whole-Body Autoradiography (QWBA)

Tissue Dissection

Micro-Autoradiography (mARG)

Our Services

Quantitative Whole-Body Autoradiography (QWBA)

QWBA is an advanced imaging technique that provides a visual map showing the tissue distribution of radiolabeled compounds within an organism. This method quantifies the concentration of a drug across different body sections, assisting researchers in understanding its distribution and potential accumulation sites.

Tissue Dissection

This traditional method involves physically harvesting organs and tissues from laboratory animals post-dosing to measure drug concentration in discrete tissues. This approach complements QWBA by offering enhanced granularity and provides detailed insights into specific tissue exposure, critical for identifying potential drug toxicity areas.

Micro-Autoradiography (mARG)

Micro-Autoradiography enables visualization of radiolabeled drug molecules at the microscopic level. This technique is particularly valuable for evaluating drug interactions at specific sites of action, such as within tumors or at cellular receptors. By integrating mARG with histological staining, we provide unparalleled insights into drug behavior at the cellular scale.

Content of Tissue Distribution Studies

Our tissue distribution studies encompass a range of evaluations to address the specific requirements of your drug development program. The following are key elements of our studies:

Biodistribution Analysis: Quantification of drug concentrations in various tissues and fluids over time.

Organ-Specific Targeting: Evaluation of selective drug accumulation in target tissues, aiding in therapeutic efficacy assessments.

Safety Assessment: Identification of off-target drug accumulation that may pose safety concerns.

Comparative Studies: Comparison of tissue distribution profiles between different formulations or delivery routes.

Regulatory Support: Generation of high-quality data to support Investigational New Drug (IND) or Clinical Trial Application (CTA) submissions.

Why Partner with Us?

Expertise in Radiochemistry: Our team comprises seasoned radiochemists with extensive experience in synthesizing and handling radiolabeled compounds.

High-Sensitivity Techniques: We employ state-of-the-art imaging and detection technologies, enabling the analysis of even low-level tissue concentrations.

Tailored Study Designs: Each study is customized to align with your specific drug development goals, ensuring optimal resource utilization.

Integrated Services: From radiolabeling to tissue analysis, we offer end-to-end solutions under one roof, ensuring consistency and efficiency.

Tissue distribution studies provide invaluable insights into the pharmacokinetics and safety profile of drug candidates. Through advanced radiochemical techniques such as QWBA, tissue dissection, and mARG, we deliver precise and comprehensive data to support your drug development goals. Our expertise, state-of-the-art technologies, and commitment to quality make us the ideal partner for your tissue distribution studies. Reach out today to learn how we can support your next breakthrough in medicine.

Please kindly note that our products and services are for research use only.

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