Introduction
Deuterated compounds, where hydrogen atoms are replaced by deuterium (2H), serve as indispensable tools in various scientific fields, particularly in nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and pharmaceutical development. In deuterated compounds, 2H and 13C doubly-labeled compounds labeled compounds, containing both the stable isotope carbon-13 (13C) and deuterium (2H), have gained prominence. Because by selectively incorporating deuterium and carbon-13 isotopes into specific positions of the molecule, researchers can track the movements of two types of atoms and determine the connectivity of different functional groups within the compound. This labeling technique is useful in diverse applications.
Applications
For structural elucidation: In molecular research, specifically in NMR spectroscopy, doubly-labeled compounds provide unmatched precision in determining the structure of complex molecules. 13C NMR spectroscopy benefits significantly from the presence of 2H as it simplifies spectra by removing interference from proton coupling, leading to clearer, more interpretable data. This is especially useful in studying large biomolecules such as proteins and nucleic acids.
Drug development and pharmacokinetics: Pharmaceutical research extensively employs doubly-labeled compounds to study the absorption, distribution, metabolism, and excretion (ADME) of drugs and to develop drug. The incorporation of deuterium into a drug candidate can improve its metabolic stability, prolonging its half-life and altering its pharmacokinetics. Additionally, carbon-13 labeling aids in traceability and quantification using mass spectrometry and NMR spectroscopy, providing a robust means to study drug distribution and degradation in vivo. Compounds labeled both 2H and 13C combine these two advantages, which are critical to understanding the efficacy and safety drug, as well as development of new drugs.
Environmental and geochemical research: Doubly-labeled compounds are valuable in environmental sciences, particularly in tracing the origins and fate of organic pollutants. Carbon-13 isotopic analysis, combined with deuterium labeling, enables detailed tracking of pollutants through different environmental compartments such as air, water, and soil. This approach helps in understanding degradation pathways and the overall impact of pollutants on ecosystems. In geochemistry, the isotopic signatures of geological samples can reveal past climatic conditions and biogeochemical cycles. Doubly-labeled compounds can be utilized as analogs to study complex interactions and processes occurring over geological timescales.
Biomedical imaging: Positron emission tomography (PET) imaging is another field where doubly-labeled compounds have significant implications. The incorporation of carbon-11 instead of carbon-13 alongside deuterium in pharmaceutical agents allows for the non-invasive tracking of biochemical processes in vivo. This dual-labeling provides enhanced resolution and specificity in imaging studies, aiding in the diagnosis and study of diseases such as cancer, Alzheimer's, and cardiovascular diseases.
What can we offer?
Compounds labeled by both 2H and 13C represent a powerful tool in the arsenal of modern scientific research. As a professional supplier of stable isotope-labeled products, Alfa Chemistry can offer all kinds of compounds labeled by both 2H and 13C. Applications of our 2H 13C labeled compounds are vast and varied, from structural elucidation using NMR spectroscopy to metabolic pathways studies, drug development, environmental monitoring, and biomedical imaging. Moreover, we ensure rapid and reliable delivery of products to meet your project timelines. If you are unable to find the product you're looking for, we also offer custom synthesis services. Don't hesitate to contact us for any assistance you may require.
Please kindly note that our products and services are for research use only.
