Radiolabeled in Vitro Metabolism Study Services - Isotope Science / Alfa Chemistry

Our Services: Comprehensive Radiolabeled Metabolism Study Solutions

Custom Radiolabeled Compound Synthesis

In Vitro Metabolism Assays

Metabolite Profiling and Quantification

Comparative Cross-Species Metabolism Studies

Our Services

Custom Radiolabeled Compound Synthesis

We offer custom solutions of radiolabeled compounds synthesis for in vitro metabolism studies. Our chemists utilize advanced techniques to ensure high radiochemical purity, stability, and specific activity for your study requirements.

In Vitro Metabolism Assays

We conduct a wide range of assays, including:

Microsomal Stability Tests: Evaluating the stability of drug candidates in liver microsomes.
Hepatocyte Studies: Investigating metabolic pathways using primary hepatocytes or cell lines.
Enzyme-Specific Studies: Identifying the role of cytochrome P450 enzymes and other metabolic proteins.

Metabolite Profiling and Quantification

Our advanced analytical platforms, including LC-MS/MS and radiometric detectors, allow precise identification and quantification of metabolites. This ensures accurate mapping of metabolic pathways and the determination of key metabolites.

Comparative Cross-Species Metabolism Studies

We specialize in investigating the metabolic similarities and differences between humans and various toxicological models, such as rodents, non-human primates, dogs, and other species. Our comprehensive approach ensures that drug developers gain a thorough understanding of species-specific metabolic profiles. By comparing metabolic rates, pathways, and metabolite formation across species, we help drug developers:

Identify species that most closely mimic human metabolism for use as toxicological models.
Predict potential interspecies differences in drug efficacy, bioavailability, or toxicity.
Pinpoint unique metabolites formed in humans that may require further investigation to ensure safety.

Case Study

A pharmaceutical company developing "Compound X" for cancer treatment, needed detailed metabolic insights before advancing clinical trials. Facing uncertainty about the compound's metabolic pathways and potential toxicity, they partnered with us for our expertise in radiolabeled in vitro metabolism studies. We designed a study using carbon-14 radiolabels, analyzed in liver microsomes and hepatocytes, to trace the compound's metabolism. By this approach, we identified key metabolites and confirmed their safety, while aligning with regulatory standards. Our findings enabled companies to support regulatory submissions with essential metabolic data and accelerated their clinical development.

Why Partner with Us?

Expertise in Radiochemistry and Metabolism: With a team of highly experienced radiochemists, pharmacologists, and toxicologists, we bring unparalleled expertise to every project.

Customized Solutions: Our tailored study designs and flexible workflows accommodate the specific needs of your compound and research goals.

Regulatory Excellence: Our services comply with global regulatory standards, ensuring that your data is robust, reproducible, and ready for submission.

Rapid Turnaround Times: We prioritize efficiency without compromising quality. Our streamlined processes enable quick delivery of high-quality data, accelerating your drug development timelines.

Radiolabeled in vitro metabolism studies are indispensable in the quest for safer and more effective drugs. Our comprehensive service portfolio, combined with unmatched expertise and state-of-the-art facilities, positions us as a trusted partner for drug developers worldwide. Let us help you navigate the complexities of radiolabeled studies and unlock the full potential of your therapeutic innovations. Reach out today to learn how we can support your next breakthrough in medicine.

Please kindly note that our products and services are for research use only.

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