Tritium Radiosynthesis Services - Isotope Science / Alfa Chemistry

Our Tritium Radiosynthesis Services

Tritium Radiosynthesis Route Design

We specialize in identifying the optimal positions within a molecule for tritium labeling, ensuring minimal interference with its biological activity and stability. Leveraging extensive experience, our team designs efficient synthetic pathways tailored to your specific needs.

Custom Synthesis of Tritium-Labeled Compounds

We can synthesize a wide range of tritium-labeled compounds according to the needs of our customers, including but not limited to:

Aromatic compounds
Steroids
Peptides and proteins
Antibody-drug conjugates (ADCs) and their linkers
Covalent binding of tritium to biomacromolecules

Heterocycles
Chiral molecules
Oligonucleotides and nucleotides
Carbohydrates
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Our Tritium Radiosynthesis Techniques

We employ a variety of synthetic techniques to deliver high-quality tritium-labeled compounds according to the chemical nature of the target molecule.

Synthetic Techniques	Description
Catalytic Reduction with Tritium Gas	It is effective for introducing tritium into double bonds or aromatic systems.
Reduction with Sodium Borohydride, [³H]	It is widely used for aldehyde and ketone reduction.
Reduction with Lithium Aluminum Hydride, [³H]	It is ideal for reducing esters and acids.
Catalytic Exchange with Tritium Gas	It is widely used for selective labeling of aromatic and unsaturated systems.
Anion Quench with Tritiated Water	It is a versatile approach for labeling acidic or nucleophilic sites.
Alkylation with Methyl Iodide, [³H]	It is commonly used for tritiating alkyl groups.
Catalytic Photoredox Tritiation	It is a cutting-edge method for high specificity labeling.
High-Specific Activity Methylation	It uses [methyl-³H] nosylate for targeted methylation.
Covalent Tritium Labeling	It utilizes [³H]NSP to tag macromolecules for bioconjugation applications.

Comprehensive Analytical Methods and Techniques Support

Our comprehensive analytical support ensures that every tritiated compound meets rigorous standards for quality and performance, and supports the fact that we can provide a complete analysis package for each project.

NMR Spectroscopy (3H-NMR): For structural confirmation and determining the position of tritium labeling.

Mass Spectrometry (LC-MS/MS): For precise molecular weight and purity analysis.

Gas Chromatography (GC): For volatile and semi-volatile compound analysis.

HPLC or UPLC: Equipped with UV and flow-through radio-detectors for compound separation and radiochemical purity assessment.

Additional Techniques: Including FT-IR, DSC, TGA, and KF for comprehensive physicochemical characterization.

GLP Compliance: Offering Good Laboratory Practice (GLP) analyses to meet regulatory standards.

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Why Partner with Us?

Comprehensive Support: End-to-end services, including synthetic design, radiosynthesis, and extensive analytical validation.

Quality Assurance: Adherence to GLP standards and rigorous quality control to ensure high reliability and reproducibility.

Custom Solutions: Tailored approaches to meet the unique needs of each client, from synthetic routes to analytical characterization.

Our goal is to empower researchers and developers with the tritium-labeled compounds they need to unlock new insights and innovations in the field of pharmaceutical field and life sciences. With our tritium radiosynthesis services, we propel your research to new height. For additional details about our services or to discuss your requirements, please reach out to us directly.

Please kindly note that our products and services are for research use only.

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