Accelerator mass spectrometry (AMS) stands as a cutting-edge analytical technique that enables the measurement of isotopic ratios with remarkable precision and sensitivity. Unlike conventional mass spectrometry, AMS accelerates ions to extraordinarily high kinetic energies before analyzing them. This acceleration enhances the separation of isotopes, allowing for the detection of rare isotopes such as carbon-14 at extremely low levels (as low as one part per quintillion), and thus making it immensely valuable in applications requiring ultra-sensitive analysis such as pharmaceutical and biopharmaceutical research. For example, AMS is frequently used to measure 14C-labeled compounds and biomacromolecule to study drug metabolism and pharmacokinetics studies. As a recognized leader in this domain, Alfa Chemistry leverages AMS to support advanced drug development processes.
Our Accelerator Mass Spectrometry (AMS) Analysis Services
At Alfa Chemistry, we specialize in applying AMS technology to pharmaceutical and biopharmaceutical research and development. With precise and reliable AMS analysis results, our services can be used to support the clinical and non-clinical studies such as metabolism, distribution, and bioanalysis (ADME/PK) studies.
For AMS analysis, we can test a wide range of sample types, including:
- Standard matrices: Plasma, whole blood, urine, and feces.
- Unusual matrices: Bile, expired air traps, dialysate, tumor biopsies, and cerebrospinal fluid (CSF).
By offering flexibility in sample analysis, we support following key studies:
Microdosing (Phase 0 Trials)
AMS enables precise analysis of ultra-low drug concentrations used in microdosing studies, providing critical pharmacokinetic data without exposing participants to significant risk.
Clinical Pharmacokinetics and Absolute Bioavailability
AMS allows for detailed quantification of drug absorption, distribution, metabolism, and excretion profiles, even at minute doses.
Mass Balance Studies
AMS can assess the complete excretion profile of a drug, ensuring accurate mass recovery and identifying metabolites.
Metabolite Analysis
AMS facilitates the precise identification and quantification of metabolites, supporting regulatory compliance and safety evaluations.
Non-Clinical Studies
AMS provides critical support for preclinical studies involving 14C-labeled drugs, helping researchers gain comprehensive insights into drug behavior and safety.
Advantages of Accelerator Mass Spectrometry (AMS)
AMS offers several distinct advantages over traditional analytical methods, particularly in pharmaceutical research:
- Ultra-Sensitivity: It can detect isotope-labeled compounds at attomolar concentrations, enabling detailed analysis of microdoses and metabolites.
- Minimal Sample Requirements: It requires only a small volume of biological material, helping save precious clinical and non-clinical samples.
- Reduced Radiation Exposure: It allows for the use of minimal isotope-labeled drug doses, reducing radiation exposure to participants while maintaining analytical accuracy.
- Versatility: It is capable of analyzing diverse sample types, from standard matrices like plasma to complex samples like tumor biopsies and CSF.
- High Precision and Accuracy: It provides reliable and reproducible data, even in challenging analytical scenarios.
- Regulatory Compliance: It meets stringent regulatory requirements for drug metabolism and pharmacokinetics studies, facilitating smoother drug approval processes.
Why Partner with Us?
Expert Team: Our team comprises highly experienced radiochemists, analyst and pharmacokinetic specialists dedicated to delivering top-notch results.
Cutting-Edge Technology: We employ state-of-the-art AMS instruments, ensuring the highest levels of sensitivity and precision.
Comprehensive Support: From study design to data interpretation, we offer end-to-end support for all AMS-related research.
Flexible Solutions: We customize our services to meet the unique needs of each project, whether routine analysis or specialized research.
Accelerator mass spectrometry (AMS) has promoted pharmaceutical research by providing ultra-sensitive, precise, and reliable analytical capabilities. With our expertise, cutting-edge technology, and commitment to excellence, Alfa Chemistry is at the forefront of AMS analysis services, enabling researchers to gain deeper insights into drug behavior, safety, and efficacy. Contact us today to learn how our solutions can support your next breakthrough in drug development.
Please kindly note that our products and services are for research use only.
