Introduction
2H 13C 15N labeled compounds are multi-isotope labeled compounds that have been labeled with deuterium (2H), carbon-13 (13C), and nitrogen-15 (15N) isotopes at specific positions within the molecule. Producing multi-isotope labeled compounds is a sophisticated process that requires meticulous planning and advanced techniques. However, once these compounds are synthesized, they will play a role that other isotopic compounds cannot match. For example, the simultaneous introduction of these isotopes into organic and biochemical compounds allows researchers to gain a more detailed insights into structural, kinetic, and mechanistic properties that are otherwise difficult to ascertain.
Main applications
Simultaneously labeled compounds with 2H, 13C, and 15N are invaluable in the fields such as biochemistry and pharmacology. Their unique ability to provide multidimensional insights makes them powerful tools in elucidating complex mechanisms and dynamics.
Structural biology: In the realm of structural biology, isotopically labeled compounds have revolutionized the way we study biomolecules. Techniques such as Nuclear Magnetic Resonance (NMR) spectroscopy and Mass Spectrometry (MS) rely heavily on labeled compounds to determine the structure and dynamics of proteins, nucleic acids, and other macromolecules. 2H, 13C, and 15N labeling is particularly beneficial as it greatly enhances the spectral resolution and allows for the observation of specific atoms within the complex structures.
Metabolic flux analysis: Understanding metabolic pathways is crucial for disciplines like metabolic engineering, disease research, and nutritional science. By using compounds labeled with 2H, 13C, and 15N, researchers can track the flow of metabolites through various biochemical pathways. This method provides quantitative data on the rates of metabolic reactions and helps identify bottlenecks or points of regulation within the metabolic network.
Drug development: Pharmaceutical research benefits immensely from isotopically labeled compounds. During drug development, labeled versions of drug candidates can be used to study pharmacokinetics and pharmacodynamics. This includes absorption, distribution, metabolism, and excretion (ADME) processes. The use of 2H, 13C, and 15N labeling allows for extremely accurate tracking of the drug and its metabolites in vivo, enabling better design and optimization of therapeutic agents.
What can we offer?
The simultaneous labeling of compounds with 2H, 13C, and 15N provides a powerful and versatile tool for a broad spectrum of scientific research. As a professional supplier of stable isotope-labeled products, Alfa Chemistry can offer all kinds of compounds that are simultaneously labeled by 2H,13C and 15N. Our labeled compounds have a significant role in various areas, from revealing the intricate details of biomolecular structures to advancing our understanding of metabolic pathways and improving drug development processes. Moreover, we ensure rapid and reliable delivery of products to meet your project timelines. If you are unable to find the product you're looking for, we also offer custom synthesis services. Don't hesitate to contact us for any assistance you may require.
Please kindly note that our products and services are for research use only.
