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Non-clinical ADME (absorption, distribution, metabolism, and excretion) studies are vital in understanding a drug's behavior within a biological system. These studies offer critical insights into how a compound interacts with the body, from the moment of administration to its elimination. Its ultimate goal is to identify any potential challenges related to safety, efficacy, and pharmacokinetics, ensuring that promising drug candidates can advance to clinical testing with confidence. Radiolabeled compounds, labeled with isotopes such as carbon-14 or tritium, are powerful tools in non-clinical ADME studies. By incorporating isotopic markers, scientists can track even minute amounts of a compound with unparalleled sensitivity and accuracy. This is particularly important when studying complex biological processes or low-abundance metabolites that might otherwise go undetected with conventional methods.
At Alfa Chemistry, our team specializes in conducting comprehensive non-clinical ADME studies using radiolabeled compounds. Through the integration of cutting-edge radiolabeling technology and rigorous analytical methodologies, our non-clinical ADME services enable drug developers to make informed decisions with confidence.
Radiolabeled In Vitro Metabolism Study Services
Alfa Chemistry provides radiolabeled in vitro metabolism study services tailored to support the multifaceted needs of drug development. Our services include custom radiolabeled compound synthesis, in vitro metabolism assays, metabolite profiling and quantification, and comparative cross-species metabolism studies.
Radiolabeled In Vivo PK/ADME Study Services
Radiolabeled compounds provide the accuracy needed to detect low-concentration metabolites and map their distribution comprehensively. Our in vivo PK/ADME study services include pharmacokinetics analysis, tissue distribution studies, excretion pathway analysis, mass balance and excretion analysis, metabolite analysis and identification (MetID), etc.
Expertise and Experience: Our team comprises seasoned scientists with extensive experience in radiolabeling chemistry and ADME studies. We have successfully conducted projects across a range of therapeutic areas.
Advanced Analytical Capabilities: We utilize cutting-edge equipment, including liquid scintillation counters, autoradiography systems, accelerator mass spectrometry (AMS) and LC-MS/MS, to achieve precise and reliable results.
Regulatory Compliance: Our facilities and processes adhere to international regulatory standards, including GLP (Good Laboratory Practice) guidelines.
Comprehensive Support: Beyond data generation, we provide comprehensive support, including detailed study reports, data interpretation, and expert consultation.
Radiolabeled compounds are transformative tools in understanding drug behavior, enabling precise and reliable ADME studies. By using radiolabeled compounds, our non-clinical ADME studies services are designed to deliver high-quality data that enhances the likelihood of clinical success. Partner with us to accelerate your drug development timelines.
Alfa Chemistry is committed to becoming a leading manufacturer and supplier focusing on providing stable isotope compounds and related services.
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