The pharmaceutical industry relies heavily on accurate and reliable analytical methods to ensure product quality, safety, and efficacy. Stable isotope-labeled compounds have emerged as indispensable tools in this regard. These compounds, containing stable isotopes such as deuterium (2H), carbon-13 (13C), nitrogen-15 (15N) and oxygen-18 (18O), offer numerous advantages over traditional analytical standards. At Alfa Chemistry, we are committed to providing high-quality SIL pharmaceutical standards to support the evolving needs of the industry. This guide is designed to help researchers choose appropriate stable isotope-labeled standards based on their specific drug types.
SIL Prescription and Nonprescription Drugs
Alfa Chemistry supplies a variety of SIL drug substances and their metabolites, covering a wide range of therapeutic areas, including:
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SIL Veterinary and Human Antibiotics
Antibiotic resistance is a global health problem that's escalating. To fight this, scientists are looking to new methods to find out how antibiotics work, resist and process. Stable isotope labelling provides an effective way to solve these problems. SIL antibiotics for drug tracebacks from food and environmental samples for food safety and health monitoring. These products aim to facilitate the most innovative research in pharmacology, toxicology and clinical studies.
Alfa Chemistry stocks a large selection of stable isotope-labeled veterinary and human antibiotics in various isotopic enrichments and chemical forms, including:
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What Can SIL Pharmaceutical Standards Be Used for?
- Quantification and identification of pharmaceutical compounds
- Pharmacokinetic studies
- Pharmacodynamic studies
- Bioavailability and bioequivalence studies
- Bioanalysis
- Environmental monitoring
- Quality control
How to Choose the Right SIL Pharmaceutical Standards?
When choosing SIL pharmaceutical standards, a few factors to keep in mind are: isotope enrichment, chemical purity, physical and compatibility with analysis method.
Taking the use of stable isotope tracers for the in vitro metabolic studies as an example, Alfa Chemistry has some suggestions for you:
- Stability of isotope labels: Stable isotope labels must be stable in vivo and not perturb the body's normal metabolic process.
- Metabolic pathways of isotope labels: in the metabolic experiments, we should know the metabolic routes and products of the selected stable isotope labels. The marker must also be completely metabolized without interfere the experimental output.
- Application of isotope markers: for in vivo metabolism experiments you need to know how to use stable isotope markers in vivo and the experiment design and the subsequent sample preparation and data analysis.
- Price of isotope markers: Markers cost more than unlabeled materials. You have to consider several parameters, including number of experiments and cycle of the experiment, and consult the experimental budget to make the experiment go as smoothly as possible.
Please kindly note that our products and services are for research use only.
