Ethanol-d6(Isotopic)

Catalog Number	ACM1516081-7
CAS	1516-08-1
Structure
Synonyms	(~2~H_5_)ethan(~2~H)ol1,1,2,2,2-Pentadeuteroethanol-dDeuterioethanol-d6Deuteroethanol-d6Ethanol-d6Ethyl-d5 alcohol-dHexadeuterioethanolHexadeuteroethanolPerdeuterioethanolPerdeuteroethanolSee more synonyms
Molecular Weight	52.11
Boiling Point	79°
Purity	99.5%
Appearance	Liquid
Storage	Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, reducings agents, acids, acid chlorides, acid anhydrides, waer, moisture, halocarbons.
Chemical Formula	C2D6O
Hazards	Highly flammable liquid and vapour.
MDL Number	MFCD00051020
Notes	Hygroscopic. Storage sensitivity: Hygroscopic. Ambient temperatures. TSCA reach: no
Size	Undefined size

Case Study

Ethanol-D6 Used to Study the Protective Effect of Ethanol on the Native Structure of Proteins

Yang, Cui, et al. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 271, 120935.

A combination of infrared (IR) spectroscopy and chemometrics were applied to investigate how secondary structure and hydration layer of human serum albumin (HSA) varied with different concentrations of ethanol interference. Specifically, deuterated water (D2O) and ethanol-d6 were used as solvents. In order to more intuitively analyze the structural changes of proteins in the infrared range, different concentrations of ethanol-d6 were introduced as interferences to dig out more information about the secondary structure and hydration layer of HSA.
The study found that the addition of ethanol-d6 increased the α-helix of HSA and reduced the disordered structure; under the action of water molecules, the hydrogen bond structure around HSA was enhanced and the intermolecular aggregation was reduced. The hypothesis was verified by adding different concentrations of ethanol-d6 and observing by circular dichroism (CD) and transmission electron microscopy (TEM). The results show that a small amount of ethanol can protect the native conformation of HSA, that is, ethanol has the potential to be a protein protectant.

Ethanol-D6 Used in the Research of Metabolic Engineering of E. Coli

Cao, Yujin, et al. Journal of Biological Research-Thessaloniki, 2020, 27, 1-10.

This work constructed an engineered strain of E. coli that can use ethanol as the sole carbon source and studied its ethanol utilization pathway. Using deuterium-labeled ethanol-D6 as a raw material, it was confirmed that the engineered E. coli strain uses ethanol as a carbon source to synthesize mevalonate.
Verification of mevalonate production from ethanol-D6
To evaluate the potential of using ethanol as a carbon source for the production of value-added chemicals, deuterium-labeled ethanol-D6 was utilized as the substrate instead of regular ethanol. The total ion current chromatogram and mass spectrum of mevalonic acid lactone produced from ethanol-D6 are presented in Fig b and d. The ion fragments of mevalonic acid lactone sourced from either ethanol or ethanol-D6 were examined. When ethanol-D6 was added to the culture media, two prominent fragments of mevalonic acid lactone at m/z 43 and 71 shifted to m/z 45 and 79, respectively. The molecular ion peak also increased by ten, changing from m/z 130 to 140. Evidence of partial incorporation of the deuterium atom is indicated by ion fragments at m/z 43, 75, and 77, suggesting that some of the hydrogen in mevalonic acid may originate from the initially introduced glucose.

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Ethanol-d6(Isotopic) (1516-08-1)

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