Premium NMR Solvents for Accurate Structural Analysis
Nuclear Magnetic Resonance (NMR) spectroscopy is the gold standard for organic structure elucidation, purity assessment, and dynamic studies. The choice of deuterated solvent directly impacts spectral resolution, lock stability, and the ability to observe exchangeable protons. Alfa Chemistry offers an extensive collection of high‑purity isotopic NMR solvents – from routine Chloroform‑d and DMSO‑d6 to specialty solvents like 2,2,2‑Trifluoroethanol‑d3, 1,1,2,2‑Tetrachloroethane‑d2, and deuterated acids/bases. All products are available with or without tetramethylsilane (TMS) as internal reference, ensuring immediate out‑of‑box usability.
Our NMR solvents are manufactured under strict quality control, delivering isotopic purity ≥99 atom% D (in most cases) and minimal residual water content. Whether you operate at 300 MHz or 900 MHz, our solvents provide clean baselines, sharp signals, and reliable field locking for academic and industrial laboratories.
Why Deuterated Solvents Are Essential for NMR
- Deuterium lock signal: The deuterium nucleus (2H) provides the frequency lock required for field‑frequency stabilization.
- Elimination of proton background: Solvent protons would otherwise overwhelm sample signals; deuteration reduces this to a negligible level.
- Quantitative analysis: High isotopic purity ensures accurate integration and reproducible quantification.
- Exchangeable proton observation: Residual water signal can be minimized, allowing clear detection of NH, OH, and SH groups.
- Wide range of chemical shifts: Choose from aprotic, protic, aromatic, aliphatic, and fluorinated deuterated solvents to match your analyte.
How to Select the Right NMR Solvent
Key considerations when choosing a deuterated solvent: sample solubility, chemical shift range, hydrogen bonding tendency, and temperature stability. For routine organic compounds, CDCl3 is the default. For polar or water‑soluble analytes, DMSO‑d6, D2O, or CD3OD are preferred. If you require a non‑coordinating environment, deuterated hydrocarbons (C6D12, C6D6, n‑octane‑d18) are ideal. We also offer solvents containing 0.03% or 1% v/v TMS as an internal reference standard (0.00 ppm).
Complete Catalog of NMR Solvents
The table below lists all available isotopic NMR solvents, organized by chemical family for easy reference. Each product is supplied in ampoules, serum bottles, or bulk containers.
Deuterated Chloroform (CDCl3) and Derivatives
Deuterated Dimethyl Sulfoxide (DMSO‑d6) and Acetone (Acetone‑d6)
Deuterated Alcohols (Methanol‑d, Methanol‑d4, Ethanol‑d6, Isopropanol‑d8, TFE, HFP)
| Catalog | Product Name | Inquiry |
|---|
| ACM1455136-5 | Methanol-d (Isotopic) | Inquiry |
| ACM811983-17 | Methanol-d4 (Isotopic), contains v/v TMS | Inquiry |
| ACM811983-18 | Methanol-d4 (Isotopic) | Inquiry |
| ACM1516081-6 | Ethanol-d6, anhydrous (Isotopic) | Inquiry |
| ACM1516081-7 | Ethanol-d6 (Isotopic) | Inquiry |
| ACM22739760-5 | 2-Propanol-d8 (Isotopic) | Inquiry |
| ACM132248589-1 | 2,2,2-Trifluoroethanol-d2 (Isotopic) | Inquiry |
| ACM77253679-4 | 2,2,2-Trifluoroethanol-d3 (Isotopic) | Inquiry |
| ACM38701745-4 | 1,1,1,3,3,3-Hexafluoro-2-propanol-d2 (Isotopic) | Inquiry |
Deuterated Hydrocarbons (Alkanes, Cyclohexane, Aromatics)
Deuterated Polar Aprotic Solvents (DMF‑d7, DMAc‑d9, THF‑d8, Dioxane‑d8, Acetonitrile‑d3, Nitromethane‑d3)
Deuterated Acids, Bases, Nitrogen Heterocycles, and Aqueous Systems
Polyols, Sweeteners, and Other Deuterated / Reference Compounds
Key NMR Solvent Families and Their Applications
- Deuterated Chloroform (CDCl3): The most widely used NMR solvent, ideal for organic compounds, natural products, and synthetic intermediates. Available with or without TMS.
- Deuterated DMSO (DMSO‑d6): Excellent for polar, aromatic, and hydrogen‑bonding compounds. High solubility for many pharmaceuticals and polymers.
- Deuterated Water (D2O): Indispensable for biological NMR, protein studies, and exchangeable proton observation (NH, OH).
- Deuterated Alcohols (Methanol‑d4, Ethanol‑d6, Isopropanol‑d8): For polar and protic analytes; allows detection of hydroxyl exchange dynamics.
- Fluorinated Deuterated Solvents (TFE‑d2, TFE‑d3, HFP‑d2): For 19F NMR, organometallic chemistry, and studies requiring weak solvating power.
- Deuterated Hydrocarbons (C6D12, C6D14, C8D18, C6D6): Used for non‑polar compounds, polymer analysis, and high‑temperature NMR.
Frequently Asked Questions
Q: What does "contains v/v TMS" mean?
A: TMS (tetramethylsilane) is added at 0.03% (or 1% for some products) as an internal chemical shift reference (0.00 ppm). This simplifies routine NMR analysis.
Q: Can I order NMR solvents without TMS?
A: Yes. Many products are offered both with and without TMS. Check the product name or contact us for TMS‑free options.
Q: What isotopic purity do these solvents have?
A: Typically ≥99 atom% D, with certain products achieving 99.5% or higher. The exact enrichment is stated on the certificate of analysis.
Q: Are these solvents suitable for cryo‑probes and high‑field instruments (≥600 MHz)?
A: Absolutely. Our solvents exhibit extremely low residual proton signals and are routinely used on 800‑900 MHz spectrometers.
Q: Do you supply bulk quantities (1L, 5L) for industrial NMR screening?
A: Yes, we offer flexible packaging from 0.5 mL ampoules to 1‑liter bottles. Bulk pricing is available upon request.
Why Choose Alfa Chemistry for NMR Solvents
✔ Broadest portfolio: over 40 deuterated solvents including rare ones (octane‑d18, xylene‑d10, TFE‑d3)
✔ High isotopic enrichment (99%‑99.9% D) with batch‑specific COA
✔ Solvents available with or without TMS reference
✔ Low residual water and metal content for sensitive NMR experiments
✔ Expert technical support and fast global delivery
Need a custom deuterated solvent or a special isotopic enrichment? Contact our NMR specialists for personalized assistance. Request a quote →
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