Modification of Existing Drugs

One of the strategies of deuterated drug development focuses on the strategic replacement of hydrogen atoms with deuterium in current drug molecules. By leveraging existing molecular scaffolds of well-known medications, this strategy reduces the uncertainty and costs associated with the de novo development of new drugs. Moreover, the strategy is particularly appealing as it enables drug creators to build upon existing clinical data and safety profiles, which expedites the path through regulatory approval processes. These benefits represent a powerful combination for delivering effective treatments more efficiently to patients. Alfa Chemistry is a pioneer in this field, leveraging cutting-edge technologies and years of expertise to design and develop high-purity deuterated drugs.

Fig.1. Structure of tetrabenazine (left) and Austedo (Right). *Austedo, a deuterated drug, was developed according to the strategy of modification of existing drug (tetrabenazine).

Core of Our Technology: Advanced Processes for Precise Deuterium Substitution

Alfa Chemistry offers deuterated drug design and development service by identifying promising drug candidates amenable to deuteration. In the strategy of modification of existing drugs, core of our technology lies in a robust understanding of catalysis, organic reactions and isotopic compound. Based on this, we have developed processes that enable precise and efficient deuterium substitution in drug molecules through years of innovation and refinement. Key aspects and superiority of our process include:

Catalytic Expertise

• Mastery of various cross-coupling reactions.
• Proficiency in C-H bond activation to facilitate site-specific deuterium incorporation.

Selective Deuteration

• Ability to target specific hydrogen atoms within complex molecular structures, ensuring minimal impact on pharmacological activity.
• Capability to avoid deuteration-induced changes that might compromise drug safety or efficacy.

High-Purity Synthesis

• Processes designed to achieve deuterium substitution with purity levels of 99% or more.
• Compliance with stringent regulatory standards to ensure product safety and efficacy.

Why Partner with Us?

Deuterated drug design represents a compelling intersection of traditional pharmacology and cutting-edge technology, offering enhanced therapeutic options across a spectrum of diseases. By capitalizing on the subtle biophysical differences imparted by deuterium, our approach to modifying existing drugs opens avenues for developing safer, more effective treatments. For additional details about our services or to discuss your requirements for deuterated drug design, please reach out to us directly.

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Modification of Existing Drugs

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