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High-Purity PPCPs Reference Materials for Environmental and Food Analysis

Stable Isotope Labeled Standards for Pharmaceuticals and Personal Care Products (PPCPs)

Pharmaceuticals and personal care products (PPCPs) are increasingly recognized as emerging environmental contaminants. They persist in water, soil, and biota, raising concerns about ecological and human health effects. Accurate quantification of PPCPs at trace levels demands high‑quality internal standards. Alfa Chemistry offers an extensive portfolio of stable isotope labeled PPCPs standards – including deuterated, 13C, 15N, and 18O labeled analogs – for LC‑MS/MS, GC‑MS, and other regulatory methods. Our products cover antibiotics, hormones, preservatives, UV filters, flame retardants, bisphenols, and many other priority pollutants.

All standards are supplied as ready‑to‑use solutions (typically 100 µg/mL or 1 mg/mL) in solvents such as methanol, acetonitrile, MTBE, nonane, or DMSO, with certified isotopic purity (≥98% atom enrichment). They meet the requirements of EPA methods, EU water framework directives, and food safety testing protocols.

Why Use Isotope Labeled PPCPs Standards?

  • Matrix effect compensation: Isotopically labeled internal standards correct for ion suppression/enhancement in complex matrices (wastewater, sludge, tissue).
  • High accuracy and precision: Match analyte behavior while providing a distinct mass shift, enabling reliable quantification at sub‑ppb levels.
  • Regulatory compliance: Essential for methods like EPA 1694, ISO 21675, and EU Decision 2015/495 on watchlist substances.
  • Multi‑residue analysis: Use mixed standard solutions to monitor dozens of PPCPs simultaneously.
  • Stable isotope dilution assay (SIDA): Gold standard for trace analysis of hormones, antibiotics, and personal care ingredients.

Complete Product Catalog by Category

The following tables list our stable isotope labeled PPCPs standards. Each product is available in certified solution form with detailed certificate of analysis.

Antibiotics & Antimicrobials

This category includes isotopically labeled sulfonamides, chloramphenicol, erythromycin, ciprofloxacin, triclosan, triclocarban, and nitrofuran metabolites (AOZ, AMOZ, AHD). These standards are essential for monitoring antibiotic residues in food, environmental waters, and wastewater treatment plant effluents. The labeled analogs compensate for matrix effects in LC‑MS/MS and enable compliance with maximum residue limits (MRLs).

CatalogProduct NameInquiry
ACM1196157900-2Sulfamethoxazole (ring-¹³C₆, 99%) 100 µg/mL in acetonitrileInquiry
ACM77643915-2Sulfamethazine (phenyl-¹³C₆, 90%) 100 µg/mL in acetonitrileInquiry
ACM1420043668(±)-Chloramphenicol (ring-D₄, benzyl-D₁, 98%) 100 µg/mL in CH3CNInquiry
ACM202114521Erythromycin (N,N-dimethyl-¹³C₂, 90%) 90-95% erythromycin AInquiry
ACM2378755059Erythromycin (N-methyl-¹³C, 99%, D₃, 98%) 100 µg/mL in MTBEInquiry
ACM2483830120Ciprofloxacin·HCl (2,3,carboxyl-¹³C₃, 99%; quinoline-¹⁵N, 98%) 100 µg/mL in methanolInquiry
ACM1365620365Triclosan (2',4,4'-trichloro-2-hydroxydiphenyl ether) (¹³C₁₂, 99%) 100 µg/mL in MTBEInquiry
ACM1365620365-1Triclosan (¹³C₁₂, 99%) 100 µg/mL in nonaneInquiry
ACMA00063561Triclocarban (3,4,4'-trichlorocarbanilide) (4'-chlorophenyl-¹³C₆, 99%) 1 mg/mL in methanolInquiry
ACMA00063562Triclocarban (4'-chlorophenyl-¹³C₆, 99%) 100 µg/mL in CH3CNInquiry
ACMA00063560Thiabendazole (ring-¹³C₆, 99%) 100 µg/mL in acetonitrileInquiry
ACMA00063563Trimethoprim (pyrimidine-4,5,6-¹³C₃, 99%) 50 µg/mL in methanolInquiry
ACM1017793940-55-(4-Morpholinylmethyl)-3-amino-2-oxazolidinone (AMOZ) (4,4,5,5',5'-D₅, 98%) 100 µg/mL in CD₃CNInquiry
ACM1188331238-33-Amino-2-oxazolidone (AOZ) (ring-D₄, 98%) 100 µg/mL in CD₃CNInquiry
ACM11882637531-Aminohydantoin hydrochloride (AHD) (5,5-D₂, 96%) 100 µg/mL in CD₃CNInquiry

Hormones & Steroids (Estrogens, Androgens, Corticosteroids)

Endocrine‑disrupting hormones are priority pollutants in water and biota. Our labeled standards include cholesterol, DHEA, cortisone, progesterone, ethynylestradiol, estrone, estradiol, and their deuterated or 13C‑labeled forms. These are critical for stable isotope dilution assays (SIDA) in human biomonitoring, wastewater analysis, and environmental fate studies.

CatalogProduct NameInquiry
ACM150044249-4Cholesterol (23,24,25,26,27-¹³C₅, 99%) 100 µg/mL in methanolInquiry
ACM78887486-3Cholesterol (3,4-¹³C₂, 99%)Inquiry
ACM83199477-4Cholesterol (25,26,26,26,27,27,27-D₇, 98%) microbiological/pyrogen testedInquiry
ACM1261254390-1Dehydroepiandrosterone (DHEA) (2,2,3,4,4,6-D₆, 98%)Inquiry
ACM1261254367-1Cortisone (2,2,4,6,6,12,12-D₇) 100 µg/mL in methanolInquiry
ACM15775743-4Progesterone (2,2,4,6,6,17A,21,21,21-D₉, 98%) 100 µg/mL in p-dioxaneInquiry
ACM2483735631-2Ethynylestradiol (20,21-¹³C₂, 99%) 100 µg/mL in acetonitrileInquiry
ACM82938065-1Estrone (3,4-¹³C₂, 90%) 100 µg/mL in acetonitrileInquiry
ACMA00063544Estradiol (3,4-¹³C₂, 99%)Inquiry
ACMA00063545Estradiol (3,4-¹³C₂, 99%) 100 µg/mL in acetonitrileInquiry
ACMA00063539DL-Estradiol (13,14,15,16,17,18-¹³C₆, 99%)Inquiry
ACMA00063540DL-Estradiol (13,14,15,16,17,18-¹³C₆, 99%) 100 µg/mL in MeOHInquiry
ACMA00063541DL-Estrone (13,14,15,16,17,18-¹³C₆, 99%)Inquiry
ACMA00063542DL-Estrone (13,14,15,16,17,18-¹³C₆, 99%) 100 µg/mL in methanolInquiry
ACM73609457-15-Androsten-3β,17β-diol (16,16,17-D₃, 98%) 100 µg/mL in methanolInquiry
ACM1217473603-23,3',5-Triiodo-L-thyronine·HCl (T3) (ring-¹³C₆, 99%) 100 µg/mL in 0.1N ammonia in methanolInquiry

Parabens (Alkyl Esters of 4-Hydroxybenzoic Acid)

Parabens are widely used as preservatives in cosmetics, pharmaceuticals, and food. They have been detected in human urine, breast milk, and environmental samples. Our deuterated and 13C‑labeled methyl, ethyl, propyl, butyl, isobutyl, isopropyl, benzyl, pentyl, and heptyl parabens serve as ideal internal standards for accurate LC‑MS/MS quantification in personal care product analysis and human biomonitoring studies.

CatalogProduct NameInquiry
ACM362049512-1Methyl paraben (methyl 4-hydroxybenzoate) (2,3,5,6-D₄, 98%) 1 mg/mL in methanol-ODInquiry
ACMA00063551Methyl paraben (methyl 4-hydroxybenzoate) (ring-¹³C₆, 99%) 1 mg/mL in methanolInquiry
ACMA00063546Ethyl paraben (ethyl 4-hydroxybenzoate) (ring-¹³C₆, 99%) 1 mg/mL in methanolInquiry
ACM1219802671-1n-Propyl paraben (n-propyl 4-hydroxybenzoate) (2,3,5,6-D₄, 98%) 1 mg/mL in methanol-ODInquiry
ACMA00063553n-Propyl paraben (n-propyl 4-hydroxybenzoate) (ring-¹³C₆, 99%) 1 mg/mL in methanolInquiry
ACM1416711539-1n-Butyl paraben (n-butyl 4-hydroxybenzoate) (ring-¹³C₆, 99%) 1 mg/mL in methanolInquiry
ACMA00063549Isobutyl paraben (isobutyl 4-hydroxybenzoate) (ring-¹³C₆, 99%) 1 mg/mL in methanolInquiry
ACMA00063550Isopropyl paraben (isopropyl 4-hydroxybenzoate) (ring-¹³C₆, 99%) 1 mg/mL in methanolInquiry
ACMA00063519Benzyl paraben (benzyl 4-hydroxybenzoate) (ring-¹³C₆, 99%) 1 mg/mL in methanolInquiry
ACM2483734978n-Pentyl paraben (n-pentyl 4-hydroxybenzoate) (¹³C₆, 99%) 1 mg/mL in methanolInquiry
ACM2483734989n-Heptyl paraben (n-heptyl 4-hydroxybenzoate) (ring-¹³C₆, 99%) 1 mg/mL in methanolInquiry

Bisphenols, Alkylphenols & Their Ethoxylates

Bisphenol A (BPA) and alkylphenols (nonylphenol, octylphenol) are high‑production volume chemicals with endocrine‑disrupting properties. Our portfolio includes labeled bisphenol F, S, AF, B, and various nonylphenol ethoxylates (mono‑, di‑, tri‑) with 13C or D labels. These standards support analysis of plastics, food contact materials, and environmental waters by LC‑MS/MS according to EPA methods.

CatalogProduct NameInquiry
ACM1794786938-1Bisphenol F (D₁₀, 98%) 100 µg/mL in methanol-ODInquiry
ACMA00063524Bisphenol F (ring-¹³C₁₂, 99%) 1 mg/mL in methanolInquiry
ACMA00063525Bisphenol F (ring-¹³C₁₂, 99%) 100 µg/mL in acetonitrileInquiry
ACM2483831281Bisphenol S (2,2',3,3',5,5',6,6'-D₈, 98%) 100 µg/mL in methanol-ODInquiry
ACMA00063527Bisphenol S (¹³C₁₂, 98%) 1 mg/mL in methanolInquiry
ACMA00063528Bisphenol S (¹³C₁₂, 98%) 100 µg/mL in methanolInquiry
ACMA00063521Bisphenol AF (ring-¹³C₁₂, 99%) 1 mg/mL in methanolInquiry
ACMA00063522Bisphenol AF (ring-¹³C₁₂, 99%) 100 µg/mL in methanolInquiry
ACMA00063523Bisphenol B (ring-¹³C₁₂, 99%) 100 µg/mL in acetonitrileInquiry
ACM211947567-1p-n-Nonylphenol (ring-¹³C₆, 99%) 1 mg/mL in methanolInquiry
ACM211947567-2p-n-Nonylphenol (ring-¹³C₆, 99%) 100 µg/mL in nonaneInquiry
ACM358730957-1p-n-Nonylphenol (ring-D₄,OD, 98%) 100 µg/mL in methanol-ODInquiry
ACMA00063557p-n-Nonylphenol (¹³C₆, 99%) 100 µg/mL in methanolInquiry
ACM1346600529p-n-Nonylphenol monoethoxylate (ring-¹³C₆, 99%) 100 µg/mL in methanolInquiry
ACM1346602116p-n-Nonylphenol diethoxylate (ring-¹³C₆, 99%) 100 µg/mL in methanolInquiry

Pharmaceutical Active Ingredients (NSAIDs, Antiepileptics, Anticoagulants, Lipid Regulators)

This group covers commonly prescribed drugs that frequently occur in wastewater: naproxen, ibuprofen, diclofenac, acetaminophen, carbamazepine, warfarin, gemfibrozil, and phenytoin. Our isotopically labeled versions (13C, D, or 15N) provide perfect internal standards for monitoring human pharmaceutical residues in the environment and for pharmacokinetic studies.

CatalogProduct NameInquiry
ACM1261392522-2DL-Naproxen (O-methyl-¹³C, 99%; O-methyl-D₃, 98%) 100 µg/mL in acetonitrileInquiry
ACM2483736350Ibuprofen (propionic-¹³C₃, 99%) 100 µg/mL in acetonitrileInquiry
ACM154523543-2Diclofenac sodium (D₄, 98%) 100 µg/mL in methanolInquiry
ACM360769217-2Acetaminophen (acetyl-¹³C₂, 99%; ¹⁵N, 98%)Inquiry
ACM360769217-3Acetaminophen (acetyl-¹³C₂, 99%; ¹⁵N, 98%) 100 µg/mL in CH3CNInquiry
ACM132183789-2Carbamazepine (D₁₀, 98%) 100 µg/mL in acetonitrile-D₃Inquiry
ACM63435687-25,5-Diphenylhydantoin (phenyl-D₅, 98%)Inquiry
ACM782132605,5-Diphenylhydantoin (2-¹³C, 99%; 1,3-¹⁵N₂, 98%) 100 µg/mL in methanolInquiry
ACM75472934-4Warfarin (phenyl-D₅, 98%) 100 µg/mL in MTBEInquiry
ACM1184986455-2Gemfibrozil (2,2-dimethyl-D₆, 98%) 100 µg/mL in dioxaneInquiry

Personal Care Products (UV Filters, Synthetic Musks, Siloxanes, Disinfectants)

This category addresses emerging contaminants from cosmetics and household products: oxybenzone (benzophenone‑3), benzophenone, synthetic musks (ketone, xylene), cyclic volatile methylsiloxanes (D3, D4, D5, D6), and triclosan/triclocarban. Our labeled standards enable precise measurement in surface water, sediment, and personal care product formulations.

CatalogProduct NameInquiry
ACMA00063555Oxybenzone (phenyl-¹³C₆, 99%) 1 mg/mL in methanolInquiry
ACMA00063556Oxybenzone (phenyl-¹³C₆, 99%) 100 µg/mL in acetonitrileInquiry
ACM22583751-2Benzophenone (D₁₀, 98%)Inquiry
ACM22583751-3Benzophenone (D₁₀, 98%) 100 µg/mL in nonaneInquiry
ACM32488485-1Benzophenone (carbonyl-¹³C, 98%)Inquiry
ACM2687960774Musk ketone (t-butyl-D₉, 98%) 100 µg/mL in acetonitrileInquiry
ACM2687960785Musk xylene (butyl-D₉, 98%) 100 µg/mL in acetonitrileInquiry
ACM2086337086Dodecamethylcyclohexasiloxane "D6" (methyl-¹³C₆, 98%) 100 µg/mL in methanolInquiry
ACMA00063529Decamethylcyclopentasiloxane "D5" (decamethyl-¹³C₁₀, 98%) 100 µg/mL in MTBEInquiry
ACMA00063548Hexamethylcyclotrisiloxane "D3" (¹³C₆, 98%) 100 µg/mL in MTBEInquiry
ACMA00063554Octamethylcyclotetrasiloxane "D4" (octamethyl-¹³C₈, 98%) 100 µg/mL in MTBEInquiry

Flame Retardants, Disinfection Byproducts, and Emerging Contaminants

This miscellaneous category includes dechlorane plus (syn/anti) flame retardants, 3‑MCPD (a food processing contaminant), trichloroanisole (cork taint), alkylphenol isomers, 4‑hydroxybenzoic acid, diethylene glycol, potassium bromate, perchlorate, and levoglucosan (biomass burning tracer). These labeled standards support specialized environmental, food safety, and industrial hygiene applications.

Frequently Asked Questions

Q: What are PPCPs and why are they monitored?
A: Pharmaceuticals and personal care products include prescription drugs, over‑the‑counter medications, fragrances, sunscreens, and preservatives. They enter the environment via wastewater and can cause ecotoxicological effects. Isotope labeled standards enable accurate quantification at trace levels.

Q: What isotopic labels are available in your PPCPs standards?
A: We offer deuterium (D), carbon‑13 (13C), nitrogen‑15 (15N), and oxygen‑18 (18O) labeled analogs, often in ready‑to‑use solutions at 100 µg/mL or 1 mg/mL.

Q: Are these standards suitable for EPA method 1694?
A: Yes, many of our products are designed to meet the requirements of EPA 1694 for pharmaceuticals and personal care products in water, soil, and biosolids.

Q: Can I get a custom mixture of multiple PPCPs standards?
A: Yes, custom multi‑component standard solutions are available upon request. Contact our technical team for your specific panel.

Q: What is the shelf life of these solutions?
A: Typically 12–24 months when stored as recommended (2‑8°C or -20°C). Each product label includes batch‑specific expiry date.

Why Choose Alfa Chemistry for PPCPs Standards?

✔ Over 120 stable isotope labeled PPCPs standards in stock
✔ Certified solution concentrations with detailed COA
✔ High isotopic purity (98‑99% atom enrichment)
✔ Solvent options: methanol, acetonitrile, MTBE, nonane, DMSO, dioxane
✔ Custom synthesis and custom concentration available
✔ Competitive pricing and fast global delivery
For a complete list of PPCPs standards, bulk orders, or custom isotope labeling services, please contact our environmental standards team. Request a quote today →

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